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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

flight
Sonneborn says he's been dismayed not only by what he sees as Trump's troubling decisions and juvenile moments but also by the president's response after a counterprotester was killed during the August white nationalist rally in Charlottesville, Virginia — which is what cemented Sonneborn's decision to seek office.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 供需双向回落 多城土地流拍
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

China does not want to see a trade war between the US and China. That would not make our trade fairer and cause loss for the both sides.
adj. 谦虚的,适度的,端庄的

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Median GMAT: 700

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

电池电力可能最终被证明是一种过渡性技术。最近电池成本的降低速度已经放慢了,特斯拉曾经承诺要在2017年生产出价格在35,000美元左右的Model 3。要实现这个目标,特斯拉的电池成本需要下降30%。相比之下,丰田(Toyota)最近的举动非常出人意料。它与特斯拉签订的电池供应协议即将期满,但丰田并未续约,而是准备加倍投入研发氢燃料电池。燃料电池的成本下降速度要快于普通电池。而且燃料电池的拥趸们认为,车主肯定会更喜欢充电速度相对更快的燃料电池,而不是要为充电等上好几个小时。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 建材市场的整治
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
祝好运、健康、佳肴伴你度过一个快乐新年。
时间:2011-06-02 编辑:beck
Supporting Actress in a Comedy: Kate McKinnon, “Saturday Night Live”

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

不管使用什么样的固有动力方式,所有这些引擎都利用最新的发动机技术,从而使性能和燃料经济最大化,其范围包括从福特嘉年华(Fiesta)的小型、高效1.0升涡轮增压三缸发动机到雪佛兰科尔维特Stingray已经被证明无可替代的巨大6.2升V8引擎。我们在本文的幻灯片里列出了《沃兹汽车》十大最佳引擎。
James Bond is one of the few constants that movie lovers have in this crazy world of ours. We seem to know that, no matter what, a new Bond movie is always on the way.
6. Now, like an addict who can't stop, Gross writes in his Tipping Point blog that QE will run to 2015. Earlier it seemed like the Bubble With No Name Yet should be renamed the Bernanke Bubble. But now, with Gross and Pimco's $2 trillion at stake here, maybe we should call it The Gross Bubble.
当年秋天开学后,达洛伊西奥开始感觉到肩上背负起了来自投资方的巨大压力。他需要改善软件的运算法则,于是他找到了以色列一个从事自然语言处理的编程团队,并签订了合同。他还用谷歌(Google)搜索找到了一位居住在泰国、在该领域有过重要著作的退休教授。达洛伊西奥说,他成了我们的科研主管,他现在在雅虎的森尼维尔办公室工作。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Despite our global economy, only 20 percent of Americans speak another language. Sixty Vocab is aiming to change that with it’s online foreign language game. Based on the premise that 2000 words equals 60 percent of a foreign language, Sixty Vocab is aiming to make learning essential vocabulary fun. The games teach the words most commonly used in conversation and applies time-based discipline — the faster you guess the word, the more rapidly you move on to the next one. Bridging the gap between your high school classes and a pricey foreign language program, Sixty Vocab is offering a unique option for those who want to learn a foreign language during their morning coffee or commute.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

支出提升三成是由更专业的创新药品,更多患者支付得起药品以及放宽专利期限这些因素驱动的。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

8. It’s never too late to start.
“一个员工离开时留了张便利贴,上面写着他走人了。”

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The report provided in-depth observations on 28 Chinese business and administrative capitals - excluding Beijing and Shanghai - using several indicators.
charm(n 吸引力;(女人的)魅力)

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 人造板甲醛释放量标准将提高
Open Access Review Article

Diagnostic technologies for COVID-19: a review

科学家指出,这增加了暴雨和洪水的危险,因为气温升高会导致大气层里积聚更多水蒸气。
我猜弗兰克-沃格尔正在试验阵容以找到能赢球的轮换阵容。但是这个阵容实在是太不均衡了,最有希望的球员没有被安置在最好的位置上。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

但是,当《老友记》第二季浓墨重彩地展现卡罗尔和苏珊的同性恋婚礼时,这个剧集就朝着人人平等的方向迈出了一大步。幕后,执行制片人玛塔·考夫曼说:"国家广播公司预计会接到成千上万的投诉电话和邮件"。然而在这部剧集上映之后,收到的恶意信件却是寥寥无几。原来,大家根本就不在乎。
现在的勇士队已经是NBA历史上最好的球队之一,你可以把他们的冠军阵容和NBA历史上的任何一支球队相提并论,因为他们打出了有史以来最好的季后赛表现。但同时也有一个“篮球”的问题。如果历史上最好的或者第二好的球员都没有机会对抗这支球队,那对这项运动的竞争力意味着什么呢?到目前为止,幸运的是这个问题并没有凸显出来,这可多亏了一个非常狂野的休赛期,但问题仍然存在:当一个最高水品的竞技体育联赛缺乏真正的竞争时,它会发生什么?
“Tangerine” (Sean Baker)
一、2016年工作回顾

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

8. 斯特吉尔·辛普森(Sturgill Simpson),《乡村音乐的大现代之声》(Matamodern Sound in Country Music),High Top Mountain。一支极为聪敏的乐队做出复古的改革:乡村乐中曾经发生过这样的事。但在斯特吉尔·辛普森突破性的第二张专辑中,他把这一点变成了可适应环境的标志,就建立在他那动人而通透的男中音之上。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

当人们还在讨论政府执法机构迫使苹果公司解锁iPhone手机来寻找证据的行为是否合法,伦敦的Fone Fun商店却开始出售一种能破解iPhone四位锁屏密码的设备,售价仅170美元。
adult成熟的,escent开始…的-开始成熟的-青春期的a,do,lescent=lesson:还在上课的年龄-青春期的

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

A number of nude photographs have been leaked online after several female students offered the photos in exchange for high-interest loans via an online lending platform.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

The S&P 500’s total return of 14% this year was 40% higher than its 25-year average annual gain. Wall Street’s chief strategists spent much of the last 12 months revising their targets higher from behind. The index printed over 50 all-time record closes, with nearly all investment management professionals racing to at least pull even. A few characteristics made the U.S. stock market particularly difficult to keep up with this year.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

The results are based on a survey of 15,870 people across the country in August and September.
4.Sex and the City Caused a Rush on Cupcakes
源于:strike(v 打击;军事进攻;铸造;敲钟;罢工)
没有比5个月前林赛·罗韩贴子中的麻木不仁和无动于衷更过分的了。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

年龄:46岁
Local farmers must love this wireless company as much as its employees do. Once a week, San Diego-based Qualcomm hosts a farmers market at two of its locations. Items sold range from traditional produce to jams and jellies. Employees with CSA veggie box subscriptions can pick up their produce packages at one of the HQ's cafés.
喜剧类最佳男配角:路易?安德森(Louie Anderson),《小丑梦摇篮》(Baskets)
In an emailed statement, FIFA said that during group stage matches, it sold a total of 143,364 of the cheapest tickets, which amounted to roughly 3,000 such tickets available per match.
adj. 代理的,副的

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Thank you to Aicha Nezzar for sharing this gem on the Facebook Group- Global English Forum.
The world's first flying bicycle flew on November 9, 1961, when Derek Pigott of the University of Southampton flew in a bicycle with an airplane-like body. It was called the Southampton University Man Powered Aircraft (sumpac). Derek furiously pedaled the air-bike to get it off the ground. It then flew 1.8 meters (about 6 ft) above the ground over a distance of 64 meters (210 ft). While the flight was short and slow, it still does not change the fact that it was the first bicycle to fly and at the same time, the first human-powered flight.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The fall in demand for industrial bulk commodities was particularly pronounced. Huge oversupply in China’s real estate and manufacturing sectors has damped investment in new capacity in recent months, denting demand for all kinds of raw materials.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 郑州首套房贷款利率上浮10%成主流
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

In this ranking of 90 European business schools, Insead in France leads the field for full-time and EMBA programmes, while the University of St Gallen in Switzerland is top for MiM. Iese of Spain and IMD of Switzerland were ranked number one for customised and open-enrolment executive education programmes respectively.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

如今,蓬勃发展的互联网经济在支撑我国信息技术(IT)行业财富增长方面正发挥着越来越重要的作用。
一个坐牢的诈骗高手爱上狱友并多次越狱,这看起来只能是小说情节,但却多少是斯蒂文·杰伊·拉塞尔的真人真事。与金·凯瑞饰演的电影主角一样,拉塞尔最初因诈骗入狱。他的男朋友吉米得了艾滋病,为了陪他,拉塞尔逃脱了这次刑罚。两年后拉塞尔被抓回监狱,不久吉米就去世了。
prime
大多数汇款出自美国(1170亿美元)、欧洲(1150亿美元)和海湾国家(1000亿美元)。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Ninety percent of the students believe their universities' guidance on entrepreneurship would help their future businesses. In addition, they professed appreciation for policies intended to encourage entrepreneurship.
China’s forex reserves — the world’s largest — have long been seen as the ultimate guarantor of financial stability, since they can be used to hedge against capital flight or to bail out domestic financial institutions struggling with a rise in bad debts.
2018年底石油价格会超过每桶70美元吗?
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

但事实上,作为一项新技术以及新运动,比特币在2014年表现出了猛烈的势头,而且在新的一年有望征服更多怀疑论者。诸多领域的指标证明了这一点:与比特币相关的初创企业和就业岗位数量大增;接受比特币的机构数量也大大增加;开发人员间的活动也较此前增强。
Coca-Cola cut its sales forecast for this year as it struggles with a consumer slowdown in China, sending the drinks group’s shares down more than 3 per cent.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

In month-on-month terms, consumer prices fell 0.1 per cent after having risen 0.7 per cent a month earlier.
该网站声称,“越喝,你(和酒瓶)就越聪明,但实际上你喝得越多,你就越醉,脑海中保留的信息也更少。
《钢铁侠3》(Iron Man 3)凭借12亿美元的票房总收入成为目前2013年最卖座影片。不过这还不足以令其主演小罗伯特·唐尼(Robert Downey Jr.)摘下我们票房收入最高演员的桂冠。今年,绰号“巨石强森”的德韦恩·约翰逊(Dwayne Johnson)凭借更加努力的工作,击败了唐尼。
On Saturday night they sang Stars from Les Miserables, the song performed the character Javert in the long-running musical.
Graham Allison, the famous Harvard professor, also warned that east Asia was headed towards the “Thucydides Trap”, adding: “When a rapidly rising power rivals an established ruling power, trouble ensues.” In early 2013, the then prime minister of Luxembourg, Jean-Claude Juncker, warned that 2013 was looking dangerously like 1913. The Economist also warned at the end of 2013, “A century on, there are uncomfortable parallels with the era that led to the outbreak of the first world war.”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

初创公司
14. 另一方面。下面是一份今年大制片公司发行,由女导演执导的粗略名单:华纳兄弟五部!包括拉娜·沃卓斯基(Lana Wachowski)、安妮·弗莱彻(Anne Fletcher)、黛娜·纳彻曼(Dana Nachman)、南希·迈耶斯(Nancy Meyers)和派翠西亚·莱根(Patricia Riggen)。环球影业三部,包括萨姆·泰勒·约翰逊(Sam Taylor Johnson)、伊丽莎白·班克斯(Elizabeth Banks)和安吉丽娜·朱莉(Angelina Jolie);迪斯尼一部,尼基·卡罗(Niki Caro)。派拉蒙零部。福克斯零部。索尼零部。我没有把福克斯和索尼的独立部门包括进去。
‘Jeopardy!’ This game show celebrated the 50th anniversary of its debut (broadcast on March 30, 1964), and proved it can still not only stump viewers but also surprise them. That’s not just because the host, Alex Trebek, briefly regrew a mustache after 13 clean-shaven years, but also because some contestants showed they could still rile an audience. This year, it was Arthur Chu, who introduced a blitzkrieg style of gamesmanship that provoked a cyber hate-fest. His strategy was thrilling and certainly effective: he came in second in the Tournament of Champions. (Ben Ingram, the nice guy, finished first.)

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

日前一份行业报告显示,2016年中国网红预计创造收益高达580亿元,远超2015年中国电影440亿元的票房收入。
理查德沃特斯(Richard Waters)

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

China's online game revenue in 2008 was CNY20.8 billion, accounting for about 27% global share, ahead of South Korea at 21% and slightly behind the U.S. at 29%, according to an earlier report by Shanghai-based market research firm iResearch. The firm also predicted that China is likely to surpass the U.S. to become the world's largest by the end of 2009.
除了作为微信核心的私聊和群卿功能之外,用户还可以通过“漂流瓶”功能寻找新的好友,具体方法是录制一段信息装在虚拟的“瓶子”里扔出去,等陌生人捡起来回复。“查看附近的人”功能与一些手机交友应用相似,用户通过它可以浏览附近其他用户的资料。另外还有一个名叫“朋友圈”的功能,用户通过它可以将相册公开分享给好友群,跟照片分享应用Instagram很像。
《一个开车从来不回头看的沙特女子》(A Saudi Woman Who Got Behind the Wheel and Never Looked Back)

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

9France
自从1995年游戏第一次面世以来,续集和新版本在之后也接踵而来。但是,对于许多仙剑迷来说,《仙剑1》激动人心又充满悲伤的故事情节是其他任何版本也代替不了的。
与去年相比,亚马逊(Amazon)、星巴克(Starbucks)和Facebook今年的品牌价值飙升。亚马逊的品牌价值增长59%,至990亿美元,排名第七,Elspeth Cheung表示,这在一定程度上源于其创造需求、而不仅仅是满足需求的能力。她表示,亚马逊的一小时送货服务对其他零售商加快送货速度构成压力,同时这家在线零售商进入物流领域对联合包裹(UPS)、联邦快递(FedEx)以及DHL等快递公司构成威胁。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

n. 改进,改善

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
From the themed collection: 图说家居上市企业老板财富排行
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The UK’s Warwick Business School recorded the best progression at the top, moving up from 16th to ninth place, while the Shanghai Advanced Institute of Finance (Saif), based at JiaoTong University, enjoys the bestprogression overall, jumping from 28th to 14th place.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

"People should just never walk away and leave their animals," Ms Lewis said. "Everyone has a legal obligation to look after animals in their care."
In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.在这欢乐的时节给你我最真的祝福和亲切的思念,愿你今年的新年比往年更璀璨。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

上周四公布的一项数据显示,两所中国顶尖大学跻身今年《泰晤士报高等教育专刊世界大学声誉排行榜》的前20名。
Starbucks, up 49 per cent to 21 in the ranking, has evolved from a café to a place where people can hang out all day since it now sells breakfast, lunch and evening meals, accompanied by alcohol in some places.
这种增长为中国电影业未来的发展奠定了坚实的基础。
9) I would rather keep people at a distance 0 1 2 3 4

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 出租房空气质量检测制度亟待建立
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

While you're studying, pay attention to the material you know will be on a test and write a quick practice question. Start a new document on your laptop and add questions as you think of them.
With most of our favorite shows on or approaching the dreaded holiday hiatus, it's time to reflect on the women that made the fall 2011 TV season so great.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 加装电子门禁 挤占消防通道
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Russian and English fans may have dominated headlines during this month's Euro 2016 football championships for their boorish, thuggish behavior.
“Soft domestic demand and the decline in commodity prices continued to weigh on China’s import growth,” said Liu Li-gang, an economist at ANZ bank. “Looking ahead, China’s export sector will continue to face significant headwinds.”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The report found that third-tier cities are most livable places.
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.
6.I Love You Phillip Morris
我们错了——最终睾丸还是与免疫系统有关联的。研究人员发现了“一扇非常小的门”使睾丸可以向免疫系统发送单向信号,这解释了为什么一些男性会被不孕症所困扰,也解释了某些癌症疫苗一直失败的原因。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

但是白人身份认同的斗争不仅仅是个政治问题,它也是一个“深藏的”故事,一个看到别人都在向前,自己却感觉困在原地的故事。
人民日报官网表示,2013年符合报考条件的人数到达历史最高——152万,2014年为141万人,这是四年来报考人数首次出现下降。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

adj. 故意的,有意的;打算中的 n. 已订婚者 v.
源于:relax(v 放松;休息)
调查显示,75%的顾客都知道可穿戴技术(无论是作为前卫的时尚潮流,还是新时代的技术工具),但是只有9%的顾客有兴趣使用它们。根据调查,仅有2%的人表示自己拥有可穿戴设备,其中大部分都是健身追踪器或智能手表。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 深圳拟调整高龄老人津贴发放标准
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

来源:前十网
7.Yes, John was with me last night. – Because that’s what friends do… we agree and ask questions later。
中美两国人民都是伟大的人民,我们有智慧来管控分歧,我们有需要也有条件来扩大共同利益。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

通常在垃圾桶里东西是没有价值的,不需要任何检查,但Qube试图用“世界上第一个智能垃圾桶”来改变这一现状。Qube声称可以帮助你监控你的垃圾,帮助你利用创新技术回收垃圾。
Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

今年,全球2000强企业来自62个国家,比起2003的首届排行榜的46个国家数量上升了。这些企业总共创造了38万亿美元的营收及3万亿美元的利润,总资产达161万亿美元,总市值则达到44万亿美元。
[.?:θ?rai'zein]
At that time, the chief executive was also under pressure, given Apple’s lack of clear product direction beyond milking the iPhone. Sensing blood, activist investors began to circle the company; first David Einhorn, then Carl Icahn, have lobbied for changes to how Apple is run and manages its finances. Mr Icahn has pushed for Apple to raise huge debt to return up to $150bn to shareholders and urged it to release more products, including a television set.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

ar一再,rog要求-一再要求-傲慢的arrow ant:一个想射箭的蚂蚁-傲慢自大的
眼见克莱斯勒的市场份额呈现死亡式螺旋下降,菲亚特会最终认识到这个不中用的公司还真就是不中用了。预计菲亚特会在8月前扬言彻底和克莱斯勒分道扬镳,除非全美汽车工人联合会(UAW)和美国纳税人作出更多让步。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

互联网P2P借贷平台在中国发展迅猛,但随之而来的是众多的诈骗案件。
n. 隧道,地道
This pseudo-comedic 1970s crime drama tells the story of two romantically involved con artists named Irving Rosenfeld and Sydney Prosser, who are caught by an FBI agent and forced to scam corrupt politicians. The two continue to manipulate the FBI agent, their political targets, and their own family members, ultimately cutting an immunity deal that allows them to escape the ordeal without any criminal charges.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: LED商业照明规模将达136.88亿元
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Chen Yu, vice-president of the China Association for Employment Promotion, said a startup may be meaningful, but one should not expect too much from it.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

联邦、州和地方政府的裁员速度开始放缓。去年各级政府部门有逾25万人失去工作。今年截至目前,约有两万人找到了工作。经济学家说,美国的债务和赤字问题引发的担忧可能将限制政府支出和投资,但基础设施支出的任何反弹都会创造就业岗位。至少政府带来的拖累会减小。[qh]
已经60岁的微软老大净资产达到750亿美元,尽管比起2015年缩水了42亿美元,却仍足以傲视群雄。自2014年超越墨西哥首富卡洛斯·斯利姆·埃卢以来,盖茨实现了福布斯富豪榜榜首三连庄。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

如果说2017年是政策制定者们开始担心“无保障无产阶级”(precariat)人数增长的一年,那么2018年将是他们尝试为此做些什么的一年。
It grows naturally into the mold's shape.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Copestake said fears over economic austerity and the stability of the euro had pushed the index of euro zone cities down in the past year while the inclusion of Caracas was due to artificially high exchange rate controls.
['treidmɑ:k]

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

最不淑女奖
The emissions growth last year was a bit slower than the average growth rate of 2.5 percent over the past decade, and much of the dip was caused by an economic slowdown in China, which is the world's single largest source of emissions. It may take an additional year or two to know if China has turned a corner toward slower emissions growth, or if the runaway pace of recent years will resume.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

5. How to play poker

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Strachan says that he believes that the IP-BOX uses the same method employed by the FBI to unlock the iPhone 5c used by Syed Farook, without Apple's help. The FBI is now offering to help other law enforcement agencies seeking to unlock an iPhone, iPad or Apple iPod touch. Apple is trying to discover how the FBI unlocked the phone so that it can issue a software update to close the vulnerability.
The other tweet was published on Inauguration Day, and Obama said, "It's been the honor of my life to serve you. You made me a better leader and a better man."
那些原本希望今年凭借战术策略获得些利益的财务顾问和资产配置人员,也在反复无常的市场中栽了跟头。全美前三位的战术策略产品中,有两款产品几乎因为高达两位数的亏损而崩盘,还有一款产品则因为向公众误报自身历史回报率而受到美国证交会调查。另一家战术产品巨头嘉信理财旗下90亿美元的Windhaven Diversified Growth产品,2014年的回报率几乎为零。战术策略原来不过如此。
“而在市场上前所未有的是确实有客户在寻找这样的投资。”

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 15个热点城市房价首现全面止涨
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

辛塔·努里亚在印度尼西亚开展她的家庭运动。她举办不同宗教信仰者参加的活动,并建立了一个进步伊斯兰女子寄宿学校网络。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

专家还指出,最近几年的人口控制政策的效果已经开始显现出来。
The parallels between Snapchat, the upstart "sexting" service, and social media behemoth Facebook (FB) in its early days are uncanny. We all know how well Zuckerberg's long bet paid off (not to mention how thoroughly he vanquished those dastardly Winklevoss twins). Could Snapchat's future be just as bright?
4. Adidas. Brand love: 35% / Rank 25

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 过百城市松绑 一二线楼市待升
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

如果你喜欢暖心且内容犀利的喜剧片,没有比《大病》更合适的了。这部影片讲述了一个喜剧演员爱上了一名抗议者的故事。他们的背景截然不同,这样的故事能让跨种族相爱的人产生共鸣。
尽管销量大幅增长让人欢欣雀跃,但它并不是汽车业今年最重大的新闻。底特律先是因为通用汽车公司(General Motors)提拔玛丽?芭拉出任汽车业首位女性首席执行官而欢欣鼓舞;紧接着,福特汽车(Ford)首席执行官艾伦?穆拉利在重回波音公司还是加入微软公司(Microsoft)两者间犹豫不决之际,它又紧张得大气都不敢喘。传统的三巨头抱怨现有产能已挖掘到极限,开始制订扩张和聘用新人的计划。特斯拉公司(Tesla)让电动汽车的销量火了一把,而且不肯按行规出牌;而同时谷歌公司(Google)则在自动汽车研制上一马当先。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

n. 平台,站台,月台,讲台,(政党的)政纲
最近两年你都没有涨薪水

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 旧楼装电梯 应引入补偿金制度
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

汉娜库赫勒(Hannah Kuchler)是驻旧金山记者

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

“常见物乱更名奖”,每年都是我的心头好。几年前,Speedo曾将泳帽改称为 “头发管理系统”(hair management system)。去年,Falke更绝,将一款袜子称作“生活问题解决方案”(Life Performance Solutions)。
大力推进社会体制改革。
粮食指数下滑约3%。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Many entrepreneurs already have a Gmail address, but not every ‘trep knows about the power of Google Docs. By utilizing Google Docs, you can instantly create shareable documents, spreadsheets and presentations that can be updated by any team member with an Internet connection. Take that “track changes”!
document
"The articles were submitted with reviewer suggestions, which had real researcher names but fabricated email addresses," Peter Butler, editorial director for cell biology and biochemistry at Springer Nature, told Shanghai-based news website The Paper.
克普克表示,就1994-95年墨西哥汇率危机而言,三个因素都起了作用,当时美联储开始以25、50甚至75个基点(1994年11月)的加息幅度进入紧缩周期。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

James Bond Themes 9. "The Man with the Golden Gun" by Lulu
奥巴马在该推文中引用曼德拉的话称:“没有人生来就因为他人的肤色、背景或宗教信仰而憎恨他们……”

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

We will continue to reform fiscal and tax systems.
Perhaps the biggest domestic threat to the 3% growth scenario would be a surprisingly swift hike in interest rates, but from all indications a dovish Federal Reserve is unlikely to take aggressive action in 2015.
The top-earning woman in the music business has been cashing in on a massive world tour, a constant stream of hit singles and a string of endorsements with a slew of major companies, while occasionally throwing thinly veiled barbs at her chief rival.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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我发现自己经常担心一些事情
The parallels between Snapchat, the upstart "sexting" service, and social media behemoth Facebook (FB) in its early days are uncanny. We all know how well Zuckerberg's long bet paid off (not to mention how thoroughly he vanquished those dastardly Winklevoss twins). Could Snapchat's future be just as bright?

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